目的 研究新疆全缘叶蓝刺头中的化学成分。方法 采用硅胶柱色谱、Sephadex LH-20 凝胶柱色谱、低压ODS柱色谱、制备薄层色谱等方法对新疆全缘叶蓝刺头的乙醇提取物进行分离纯化,运用现代光谱技术鉴定化合物结构。结果 从新疆全缘叶蓝刺头中分离得到6种黄酮醇类化合物和3种简单酚类化合物,分别为金圣草素(L-1),槲皮素-3-O-β-D-吡喃葡萄糖苷(L-2),异鼠李素-3-O-2G-吡喃鼠李糖基芸香糖苷(L-3),Sowie Spinacetin-3-O-β-D-吡喃葡萄糖苷(L-4),5, 7, 4′-三羟基-3, 6-二甲氧基黄酮(L-5),芦丁(L-6),2, 6-二甲氧基对苯醌(L-7),3, 5-二甲氧基-4-羟基-苯基-1-O-β-D-吡喃葡萄糖苷(L-8)和熊果苷(L-9)。结论 化合物L-2~L-5,L-7~L-9为首次从蓝刺头属中分离得到。
Abstract
OBJECTIVE To investigate the chemical constituents of Echinops integrifolius from XinJiang. METHODS The compounds were isolated by chromatography on silica gel, Sephadex LH-20, and ODS C18 columns and preparative thin layer chromatography. RESULTS Six flavonols and three phenolic compounds were isolated and identified as 5, 7, 4′-trihydroxy-3-methanoxyflavone (L-1), quercetin-3-O-β-D-glucopyranoside (L-2), isorhamnetin 3-O-2G-rhamnopyranosylrutinoside (L-3), Sowie Spinacetin 3-O-β-D-glucopyranoside (L-4), 5, 7, 4′-Trihydroxy-3,6-dimethoxyflavone (L-5), rutin(L-6), 2, 6-dimethoxy-1, 4-benzoquinone (L-7), 3, 5-dimethoxy-4-hydroxypheny1-O-β-D-glucopyranoside (L-8) and arbutin(L-9). CONCLUSION Compounds L-2-L-5,L-7-L-9 were isolated from Echinops genus for the first time.
关键词
全缘叶蓝刺头 /
黄酮醇类化合物 /
酚类成分 /
金圣草素 /
槲皮素-3-O-β-D-吡喃葡萄糖苷 /
异鼠李素-3-O-2G-吡喃鼠李糖基芸香糖苷
{{custom_keyword}} /
Key words
Echinops integrifolius /
flavonols /
phenic compounds /
5, 7, 4'- trihydroxy-3-methanoxyflavone /
quercetin-3-O-β-D-glucopyranoside /
isorhamnetin 3-O-2G-rhamnopyranosylrutinoside
{{custom_keyword}} /
中图分类号：
R284
{{custom_clc.code}}
({{custom_clc.text}})
{{custom_sec.title}}
{{custom_sec.title}}
{{custom_sec.content}}
参考文献
[1] Flora of China Editor Committee of Chinese Academy of Science. Flora of China (中国植物志). Beijing:Science Press, 1978:1-19.[2] WU Y M. Studies on the chemical constituents of alkaloids in Echinops latifolius Tausch and Corydalis decumbens (Thunb.) Pers.. Nanjing:Jiangsu University, 2007.[3] FRANCOIS S, CELINE D, ULUGBEK K, et al. Chemical constitutes from Echinops integrifolius..Biochem Syst Ecol, 2013, 47:42-44.[4] XU J Z, ZENG S S, QU H B. Chemical constituents from Viola yedoensis. Chin Tradit Herb Drugs (中草药), 2010, 41(9):1423-1425.[5] KOHEI K, NAONOBU N, MASAHIKO S. Malonylated flavonol glycosides from the petals of Clitoria ternatea. Phytochemistry, 2003, 62:229-237.[6] HIDEYUKI I, EISEI N, TAKAO K, et al. Flavonoid and benzophenone glycosides from Coleogyne ramosissima . Phytochemistry, 2000, 54:695-700.[7] IRMGARD M, DETLEF W. Flavonoid glycosides from Arnica montana and Arnica chamissonis. Planta Med, 1987, 53:434-437.[8] HEERDEN F R V, VILJOEN A M, WYK B-E V. The major flavonoid of Dodonaea angustifolia. Fitoterapia, 2000, 71:602-604.[9] PARK K M, YANG M C, LEE K H, et al. Cytotoxic phenolic constituents of Acer tegmentosum maxim. Archives Pharm Res, 2006, 29:1086-1090.[10] LIN P C, LI S, WANG S J, et al. Phenolic constituents in Embelia ribes. Chin Tradit Herbal Drugs (中草药), 2006, 37(6):818-821.[11] LI Y, WANG C L, WANG F F, et al. Phenolic components and flavanones from Dendrobium candidium. Chin Pharm J(中国药学杂志),2010,45(13):975-979.[12] BERNARDO A F, MARTHA V E, ROSA E, et al. A new languidulane diterpenoid from Salvia mexicana var. mexicana. Molecules, 2011, 16:8866-8873.
{{custom_fnGroup.title_cn}}
脚注
{{custom_fn.content}}
基金
国家“重大新药创制”项目(2011ZX09307-002-01);国家自然科学基金资助项目(31000160);大连市科技基金项目(2011J21DW012)
{{custom_fund}}
PDF(609 KB)
